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ALNY

Alnylam Pharmaceuticals, Inc.

Price Chart
Latest Quote

$303.87

+0.23 (+0.08%)
Current Price
Previous Close $303.64
Open $304.62
Day High $306.34
Day Low $302.16
Volume 321,603
Fetched: 2026-06-05T16:22:42
Stock Information
Shares Outstanding 133.51M
Total Debt $2.97B
Cash Equivalents $3.01B
Revenue $4.29B
Net Income $537.99M
Sector Healthcare
Industry Biotechnology
Market Cap $40.46B
P/E Ratio 76.34
EPS (TTM) $3.97
Exchange NMS
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📊 Comprehensive Analysis
Company Data
Enterprise Value$40.42B
Sales$4.29B
Income$537.99M
Book/sh$8.06
Cash/sh$22.54
Employees2K
Financial Ratios
Quick Ratio2.88
Current Ratio3.13
Debt/Eq276.20
Returns & Margins
ROA10.06%
ROE90.36%
Gross Margin80.83%
Operating Margin23.02%
Profit Margin12.55%
Ownership
Insider Ownership0.18%
Institutional Ownership102.06%
Insider & Institutional transactions data not available
Valuation Ratios
Forward P/E21.81
PEG0.52
P/S9.44
P/B37.60
Analyst Data
Recommendationbuy
Target Price$445.81
Technical Indicators
SMA20$295.00
SMA50$307.22
SMA200$381.85
RSI62.07
ATR9.4164
Shares Float132.94M
Short Float5.39%
Short Ratio4.81
Volatility0.27
Rel Volume1.02
Performance History
Week+0.35%
Month+0.02%
Quarter-5.49%
6 Months-35.97%
YTD-24.27%
Year-0.74%
3 Years+63.80%
5 Years+113.43%
10 Years+317.42%
Stock Score: ⭐ Premium
Based on debt, profitability, growth, and cash flow metrics
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Recent Price History
Date Close Volume
2026-06-05 $303.05 1,003,600
2026-06-04 $303.64 1,081,400
2026-06-03 $292.58 988,800
2026-06-02 $286.12 1,042,500
2026-06-01 $295.63 1,186,000
2026-05-29 $301.98 2,278,000
2026-05-28 $305.06 1,020,700
2026-05-27 $295.63 629,500
2026-05-26 $295.50 649,700
2026-05-22 $297.45 681,300
2026-05-21 $300.51 650,200
2026-05-20 $298.48 799,200
2026-05-19 $294.30 769,900
2026-05-18 $286.27 873,400
2026-05-15 $286.98 1,149,400
2026-05-14 $293.45 889,700
2026-05-13 $291.48 975,800
2026-05-12 $292.03 826,100
2026-05-11 $284.84 1,287,600
2026-05-08 $295.05 926,800
2026-05-07 $295.91 1,144,000
2026-05-06 $303.00 1,012,300
About Alnylam Pharmaceuticals, Inc.

Alnylam Pharmaceuticals, Inc. discovers, develops, manufactures, and commercializes therapeutics based on ribonucleic acid interference in the United States, Europe, and internationally. The company offers ONPATTRO for hereditary transthyretin-mediated (hATTR) amyloidosis; AMVUTTRA for ATTR and hATTR amyloidosis; Leqvio for hypercholesterolemia; Qfitlia for hemophilia A or B; GIVLAARI for acute hepatic porphyria; and OXLUMO for primary hyperoxaluria type 1. It also develops a range of products in Phase 3 trial, such as Nucresiran for ATTR amyloidosis; Zilebesiran for hypertension; Cemdisiran for myasthenia gravis, paroxysmal nocturnal hemoglobinuria, and geographic atrophy; and Elebsiran for hepatitis D virus infections. In addition, the company is developing various products in Phase 2 trial, including Rapirosiran for metabolic dysfunction-associated steatohepatitis; ALN-ANG3 for diabetic kidney disease; ALN-4324 for type 2 diabetes mellitus; Mivelsiran for cerebral amyloid angiopathy, as well as in Phase 1 trial for Alzheimer's disease; and ALN-6400 for bleeding disorders. Further, it develops a range of products in Phase 1 trial, such as ALN-2232 for obesity and weight management; ALN-PNP for non-alcoholic fatty liver disease; ALN-APOC3 for dyslipidemia; ALN-CIDEB for metabolic dysfunction-associated steatohepatitis; ALN-HTT02 for Huntington's disease; ALN-5288 for Alzheimer's disease; ALN-SOD for SOD1 amyotrophic lateral sclerosis; ALN-SNCA for Parkinson's disease; AG-236 for polycythemia vera; ALN-CFB for paroxysmal nocturnal hemoglobinuria; ALN-BCAT for hepatocellular carcinoma; and ALN-4285, ALN-4915, and ALN-F1202 for healthy volunteers. The company has collaborations with Regeneron Pharmaceuticals, Inc.; Roche Holding AG; Sanofi S.A.; Novartis AG; PeptiDream, Inc; Dicerna Pharmaceuticals, Inc.; and Ionis Pharmaceuticals, Inc. Alnylam Pharmaceuticals, Inc. was founded in 2002 and is headquartered in Cambridge, Massachusetts.

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Income Statement (Annual)
Metric 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Revenue
Reconciled Cost Of Revenue $681,871,000 $323,370,000 $310,406,000 $168,817,000
Cost Of Revenue $681,871,000 $323,370,000 $310,406,000 $168,817,000
Total Revenue $3,713,937,000 $2,248,243,000 $1,828,292,000 $1,037,418,000
Operating Revenue $3,713,937,000 $2,248,243,000 $1,828,292,000 $1,037,418,000
Expenses
Interest Expense $252,627,000 $141,858,000 $121,221,000 $155,968,000
Total Expenses $3,212,359,000 $2,425,128,000 $2,110,467,000 $1,822,490,000
Rent Expense Supplemental $193,435,000 $169,909,000 $145,687,000 $131,967,000
Other Income Expense $-37,269,000 $-180,624,000 $-125,682,000 $-210,761,000
Other Non Operating Income Expenses $7,510,000 $-6,832,000 $-17,741,000 $-6,204,000
Net Non Operating Interest Income Expense $-141,157,000 $-19,866,000 $-25,660,000 $-131,160,000
Interest Expense Non Operating $252,627,000 $141,858,000 $121,221,000 $155,968,000
Operating Expense $2,530,488,000 $2,101,758,000 $1,800,061,000 $1,653,673,000
General And Administrative Expense $1,210,713,000 $975,526,000 $795,646,000 $770,658,000
Income & Earnings
Net Income From Continuing Operation Net Minority Interest $313,747,000 $-278,157,000 $-440,242,000 $-1,131,156,000
Net Interest Income $-141,157,000 $-19,866,000 $-25,660,000 $-131,160,000
Interest Income $111,470,000 $121,992,000 $95,561,000 $24,808,000
Normalized Income $357,227,409 $-150,072,296 $-354,968,610 $-969,555,970
Net Income From Continuing And Discontinued Operation $313,747,000 $-278,157,000 $-440,242,000 $-1,131,156,000
Total Operating Income As Reported $501,578,000 $-176,885,000 $-282,175,000 $-785,072,000
Net Income Common Stockholders $313,747,000 $-278,157,000 $-440,242,000 $-1,131,156,000
Net Income $313,747,000 $-278,157,000 $-440,242,000 $-1,131,156,000
Net Income Including Noncontrolling Interests $313,747,000 $-278,157,000 $-440,242,000 $-1,131,156,000
Net Income Continuous Operations $313,747,000 $-278,157,000 $-440,242,000 $-1,131,156,000
Pretax Income $323,152,000 $-377,375,000 $-433,517,000 $-1,126,993,000
Special Income Charges $-42,473,000 $0 $0 $-76,586,000
Interest Income Non Operating $111,470,000 $121,992,000 $95,561,000 $24,808,000
Operating Income $501,578,000 $-176,885,000 $-282,175,000 $-785,072,000
Gross Profit $3,032,066,000 $1,924,873,000 $1,517,886,000 $868,601,000
Per Share
Diluted EPS $2.33 $-2.18 $-3.52 $-9.30
Basic EPS $2.39 $-2.18 $-3.52 $-9.30
Other
Tax Effect Of Unusual Items $-1,298,591 $-45,707,296 $-22,667,610 $-42,956,970
Tax Rate For Calcs $0 $0 $0 $0
Normalized EBITDA (Bullshit earnings) $676,216,000 $-5,055,000 $-150,301,000 $-722,000,000
Total Unusual Items $-44,779,000 $-173,792,000 $-107,941,000 $-204,557,000
Total Unusual Items Excluding Goodwill $-44,779,000 $-173,792,000 $-107,941,000 $-204,557,000
Reconciled Depreciation $55,658,000 $56,670,000 $54,054,000 $44,468,000
EBITDA (Bullshit earnings) $631,437,000 $-178,847,000 $-258,242,000 $-926,557,000
EBIT $575,779,000 $-235,517,000 $-312,296,000 $-971,025,000
Diluted Average Shares $134,684,000 $127,651,000 $124,906,000 $121,689,000
Basic Average Shares $131,004,000 $127,651,000 $124,906,000 $121,689,000
Diluted NI Availto Com Stockholders $313,747,000 $-278,157,000 $-440,242,000 $-1,131,156,000
Tax Provision $9,405,000 $-99,218,000 $6,725,000 $4,163,000
Other Special Charges $42,473,000 - - $76,586,000
Gain On Sale Of Security $-2,306,000 $-173,792,000 $-107,941,000 $-127,971,000
Research And Development $1,319,775,000 $1,126,232,000 $1,004,415,000 $883,015,000
Selling General And Administration $1,210,713,000 $975,526,000 $795,646,000 $770,658,000
Other Gand A $348,976,000 $274,539,000 $226,664,000 $226,941,000
Rent And Landing Fees $193,435,000 $169,909,000 $145,687,000 $131,967,000
Salaries And Wages $668,302,000 $531,078,000 $423,295,000 $411,750,000
Fetched: 2026-05-30
Balance Sheet (Annual)
Metric 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Assets
Net Tangible Assets $789,176,000 $67,088,000 $-220,644,000 $-158,223,000
Total Assets $4,966,331,000 $4,239,983,000 $3,829,880,000 $3,546,359,000
Total Non Current Assets $915,669,000 $944,698,000 $847,183,000 $854,112,000
Other Non Current Assets $81,631,000 $133,903,000 $111,293,000 $115,482,000
Non Current Deferred Assets $125,975,000 $116,863,000 $10,101,000 -
Non Current Deferred Taxes Assets $125,975,000 $116,863,000 $10,101,000 -
Current Assets $4,050,662,000 $3,295,285,000 $2,982,697,000 $2,692,247,000
Other Current Assets $281,892,000 $116,964,000 $126,382,000 $132,916,000
Inventory $82,719,000 $78,509,000 $89,146,000 $128,962,000
Receivables $777,567,000 $405,308,000 $327,787,000 $237,963,000
Accounts Receivable $777,567,000 $405,308,000 $327,787,000 $237,963,000
Cash Cash Equivalents And Short Term Investments $2,908,484,000 $2,694,504,000 $2,439,382,000 $2,192,406,000
Cash And Cash Equivalents $1,657,250,000 $966,428,000 $812,688,000 $866,394,000
Prepaid Assets - - - -
Debt
Total Debt $1,278,389,000 $1,296,048,000 $1,305,387,000 $1,320,248,000
Long Term Debt And Capital Lease Obligation $1,232,871,000 $1,254,162,000 $1,263,877,000 $1,278,281,000
Long Term Debt $1,007,784,000 $1,024,621,000 $1,020,776,000 $1,016,942,000
Current Debt And Capital Lease Obligation $45,518,000 $41,886,000 $41,510,000 $41,967,000
Net Debt - $58,193,000 $208,088,000 $150,548,000
Liabilities
Total Liabilities Net Minority Interest $4,177,155,000 $4,172,895,000 $4,050,524,000 $3,704,582,000
Total Non Current Liabilities Net Minority Interest $2,710,806,000 $2,986,623,000 $3,082,738,000 $2,936,667,000
Other Non Current Liabilities $1,477,935,000 $1,339,322,000 $1,630,686,000 $1,464,595,000
Derivative Product Liabilities $0 $393,139,000 - -
Current Liabilities $1,466,349,000 $1,186,272,000 $967,786,000 $767,915,000
Other Current Liabilities $220,068,000 $206,798,000 $54,991,000 $40,289,000
Current Deferred Liabilities $4,845,000 $55,481,000 $102,753,000 $42,105,000
Payables And Accrued Expenses $938,721,000 $667,708,000 $646,362,000 $512,864,000
Payables $115,721,000 $88,415,000 $55,519,000 $98,094,000
Accounts Payable $115,721,000 $88,415,000 $55,519,000 $98,094,000
Non Current Deferred Liabilities - $0 $188,175,000 $193,791,000
Equity
Common Stock Equity $789,176,000 $67,088,000 $-220,644,000 $-158,223,000
Total Equity Gross Minority Interest $789,176,000 $67,088,000 $-220,644,000 $-158,223,000
Stockholders Equity $789,176,000 $67,088,000 $-220,644,000 $-158,223,000
Gains Losses Not Affecting Retained Earnings $-20,097,000 $-34,518,000 $-23,375,000 $-44,654,000
Other Equity Adjustments $-20,097,000 $-34,518,000 $-23,375,000 $-44,654,000
Retained Earnings $-6,702,524,000 $-7,287,748,000 $-7,009,591,000 $-6,569,349,000
Other
Ordinary Shares Number $132,376,000 $129,294,000 $125,794,000 $123,925,000
Share Issued $132,376,000 $129,294,000 $125,794,000 $123,925,000
Tangible Book Value $789,176,000 $67,088,000 $-220,644,000 $-158,223,000
Invested Capital $1,796,960,000 $1,091,709,000 $800,132,000 $858,719,000
Working Capital $2,584,313,000 $2,109,013,000 $2,014,911,000 $1,924,332,000
Capital Lease Obligations $270,605,000 $271,427,000 $284,611,000 $303,306,000
Total Capitalization $1,796,960,000 $1,091,709,000 $800,132,000 $858,719,000
Additional Paid In Capital $7,510,473,000 $7,388,061,000 $6,811,063,000 $6,454,540,000
Capital Stock $1,324,000 $1,293,000 $1,259,000 $1,240,000
Common Stock $1,324,000 $1,293,000 $1,259,000 $1,240,000
Preferred Stock $0 $0 $0 $0
Long Term Capital Lease Obligation $225,087,000 $229,541,000 $243,101,000 $261,339,000
Current Deferred Revenue $4,845,000 $55,481,000 $102,753,000 $42,105,000
Current Capital Lease Obligation $45,518,000 $41,886,000 $41,510,000 $41,967,000
Pensionand Other Post Retirement Benefit Plans Current $257,197,000 $214,399,000 $122,170,000 $130,690,000
Current Accrued Expenses $823,000,000 $579,293,000 $590,843,000 $414,770,000
Net PPE $708,063,000 $693,932,000 $725,789,000 $738,630,000
Accumulated Depreciation $-322,700,000 $-270,364,000 $-223,076,000 $-173,450,000
Gross PPE $1,030,763,000 $964,296,000 $948,865,000 $912,080,000
Leases $241,077,000 $236,686,000 $235,411,000 $230,848,000
Construction In Progress $40,954,000 $7,674,000 $30,099,000 $14,595,000
Other Properties $384,794,000 $362,167,000 $354,855,000 $343,033,000
Machinery Furniture Equipment $57,240,000 $54,181,000 $47,769,000 $45,202,000
Buildings And Improvements $297,618,000 $294,508,000 $271,651,000 $269,322,000
Land And Improvements $9,080,000 $9,080,000 $9,080,000 $9,080,000
Properties $0 $0 $0 $0
Other Short Term Investments $1,251,234,000 $1,728,076,000 $1,626,694,000 $1,326,012,000
Non Current Deferred Revenue - $0 $188,175,000 $193,791,000
Treasury Shares Number - - $0 -
Inventories Adjustments Allowances - - - $-32,700,000
Other Inventories - - - $-42,000
Finished Goods - - - $25,606,000
Work In Process - - - $113,783,000
Raw Materials - - - $22,315,000
Fetched: 2026-05-30
Cash Flow Statement (Annual)
Metric 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Free Cash Flow
Free Cash Flow $465,383,000 $-42,589,000 $41,945,000 $-613,333,000
Operating Activities
Operating Cash Flow $524,080,000 $-8,312,000 $104,156,000 $-541,274,000
Cash Flow From Continuing Operating Activities $524,080,000 $-8,312,000 $104,156,000 $-541,274,000
Operating Gains Losses $2,306,000 $173,792,000 $107,941,000 $204,557,000
Investing Activities
Capital Expenditure $-58,697,000 $-34,277,000 $-62,211,000 $-72,059,000
Investing Cash Flow $436,329,000 $-116,840,000 $-336,350,000 $169,354,000
Cash Flow From Continuing Investing Activities $436,329,000 $-116,840,000 $-336,350,000 $169,354,000
Net Other Investing Changes $-2,150,000 $-19,317,000 $-4,438,000 $-13,194,000
Financing Activities
Financing Cash Flow $-305,190,000 $294,159,000 $172,131,000 $425,753,000
Cash Flow From Continuing Financing Activities $-305,190,000 $294,159,000 $172,131,000 $425,753,000
Net Other Financing Charges $-10,686,000 $-8,792,000 $24,667,000 $-87,611,000
Issuance Of Capital Stock - - - $0
Net Common Stock Issuance - - - $0
Common Stock Issuance - - - $0
Other
Repayment Of Debt $-1,190,224,000 $0 $0 $-762,107,000
Issuance Of Debt $645,692,000 $0 $0 $1,016,111,000
Interest Paid Supplemental Data $218,707,000 $67,578,000 $32,118,000 $45,235,000
End Cash Position $1,658,807,000 $968,652,000 $814,884,000 $868,556,000
Beginning Cash Position $968,652,000 $814,884,000 $868,556,000 $822,153,000
Effect Of Exchange Rate Changes $34,936,000 $-15,239,000 $6,391,000 $-7,430,000
Changes In Cash $655,219,000 $169,007,000 $-60,063,000 $53,833,000
Proceeds From Stock Option Exercised $250,028,000 $302,951,000 $147,464,000 $259,360,000
Net Issuance Payments Of Debt $-544,532,000 $0 $0 $254,004,000
Net Long Term Debt Issuance $-544,532,000 $0 $0 $254,004,000
Long Term Debt Payments $-1,190,224,000 $0 $0 $-762,107,000
Long Term Debt Issuance $645,692,000 $0 $0 $1,016,111,000
Net Investment Purchase And Sale $497,176,000 $-63,246,000 $-269,701,000 $254,607,000
Sale Of Investment $1,802,257,000 $1,571,665,000 $1,553,800,000 $2,231,568,000
Purchase Of Investment $-1,305,081,000 $-1,634,911,000 $-1,823,501,000 $-1,976,961,000
Net PPE Purchase And Sale $-58,697,000 $-34,277,000 $-62,211,000 $-72,059,000
Purchase Of PPE $-58,697,000 $-34,277,000 $-62,211,000 $-72,059,000
Change In Working Capital $-444,782,000 $-214,084,000 $57,261,000 $7,618,000
Change In Other Working Capital $-50,635,000 $-235,446,000 $55,022,000 $-65,911,000
Change In Payables And Accrued Expense $75,066,000 $91,093,000 $80,840,000 $191,769,000
Change In Payable $75,066,000 $91,093,000 $80,840,000 $191,769,000
Change In Account Payable $75,066,000 $91,093,000 $80,840,000 $191,769,000
Change In Prepaid Assets $-117,724,000 $3,229,000 $-9,029,000 $-38,507,000
Change In Inventory $8,474,000 $13,590,000 $18,367,000 $-34,136,000
Change In Receivables $-359,963,000 $-86,550,000 $-87,939,000 $-45,597,000
Changes In Account Receivables $-359,963,000 $-86,550,000 $-87,939,000 $-45,597,000
Other Non Cash Items $251,114,000 $88,145,000 $104,175,000 $104,023,000
Stock Based Compensation $348,235,000 $272,084,000 $221,680,000 $230,649,000
Deferred Tax $-2,198,000 $-106,762,000 $-713,000 $-1,433,000
Deferred Income Tax $-2,198,000 $-106,762,000 $-713,000 $-1,433,000
Depreciation Amortization Depletion $55,658,000 $56,670,000 $54,054,000 $44,468,000
Depreciation And Amortization $55,658,000 $56,670,000 $54,054,000 $44,468,000
Gain Loss On Investment Securities $2,306,000 $173,792,000 $107,941,000 $127,971,000
Net Income From Continuing Operations $313,747,000 $-278,157,000 $-440,242,000 $-1,131,156,000
Income Tax Paid Supplemental Data - $14,360,000 $6,021,000 $2,654,000
Change In Other Current Liabilities - - $-46,502,000 $-43,171,000
Depreciation - - $97,031,000 $85,550,000
Fetched: 2026-05-30