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IONS

Ionis Pharmaceuticals, Inc.

Price Chart
Latest Quote

$78.45

+1.94 (+2.53%)
Current Price
Previous Close $76.52
Open $76.69
Day High $79.55
Day Low $76.26
Volume 1,640,076
Fetched: 2026-06-25T18:45:10
Stock Information
Shares Outstanding 165.26M
Total Debt $2.61B
Cash Equivalents $1.98B
Revenue $1.06B
Net Income $-326.98M
Sector Healthcare
Industry Biotechnology
Market Cap $12.97B
EPS (TTM) $-2.01
Exchange NMS
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📊 Comprehensive Analysis
Company Data
Enterprise Value$13.28B
Sales$1.06B
Income$-326.98M
Book/sh$2.96
Cash/sh$11.96
Employees1K
Financial Ratios
Quick Ratio2.86
Current Ratio4.10
Debt/Eq531.05
Returns & Margins
ROA-7.03%
ROE-67.62%
Gross Margin10.94%
Operating Margin-47.72%
Profit Margin-30.90%
Ownership
Insider Ownership0.61%
Institutional Ownership107.27%
Insider & Institutional transactions data not available
Valuation Ratios
Forward P/E-105.49
PEG27.33
P/S12.25
P/B26.49
Analyst Data
Recommendationbuy
Target Price$105.91
Technical Indicators
SMA20$74.82
SMA50$74.97
SMA200$75.32
RSI63.60
ATR2.1661
Shares Float163.97M
Short Float13.64%
Short Ratio9.45
Volatility0.37
Rel Volume0.91
Performance History
Week+5.58%
Month+3.14%
Quarter+7.92%
6 Months-3.55%
YTD-1.53%
Year+97.92%
3 Years+91.03%
5 Years+109.32%
10 Years+280.48%
Stock Score: ⭐ Premium
Based on debt, profitability, growth, and cash flow metrics
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Recent Price History
Date Close Volume
2026-06-25 $78.46 1,640,076
2026-06-24 $76.52 2,485,200
2026-06-23 $75.99 1,405,400
2026-06-22 $75.89 1,956,100
2026-06-18 $74.12 2,984,400
2026-06-17 $74.31 1,788,200
2026-06-16 $73.09 1,801,400
2026-06-15 $73.96 1,506,300
2026-06-12 $73.28 1,964,900
2026-06-11 $73.82 2,234,400
2026-06-10 $73.32 1,595,700
2026-06-09 $74.58 1,568,700
2026-06-08 $73.54 1,620,700
2026-06-05 $74.48 1,982,000
2026-06-04 $75.13 1,240,800
2026-06-03 $73.82 1,303,900
2026-06-02 $72.97 2,086,200
2026-06-01 $75.38 1,467,700
2026-05-29 $76.50 1,675,600
2026-05-28 $77.33 1,603,000
2026-05-27 $76.49 1,341,300
2026-05-26 $76.07 1,279,200
About Ionis Pharmaceuticals, Inc.

Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; DAWNZERA for prophylaxis to prevent attacks of hereditary angioedema in adults; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult patients with spinal muscular atrophy (SMA). It also provides QALSODY for the treatment of Amyotrophic Lateral Sclerosis (ALS); TEGSEDI for the treatment of ATTRv-PN in adults; and WAYLIVRA for treatment for FCS and familial partial lipodystrophy. It also develops products under Phase 3 clinical trials, such as Olezarsen for patients with hypertriglyceridemia (SHTG) and cardiovascular disease (CVD); and Zilganerse, a potential treatment for people with genetically confirmed Alexander disease, as well as ION582 which is in Phase 3 clinical trial for the potential treatment of AS, a rare genetic neurological disease. In addition, the company develops Eplontersen to degrade mutant and wild-type TTR mRNA through binding to the TTR mRNA; Pelacarsen to inhibit the production of apolipoprotein(a) in the liver to offer a direct approach for reducing lipoprotein(a); Bepirovirsen to inhibit the production of viral proteins associated with hepatitis B virus; Sefaxersen to reduce the production of complement factor B and lower activation of the alternative complement pathway; and Ulefnersen to reduce the production of the fused in sarcoma, as well as other mid-stage pipeline investigational medicines. It has a strategic collaboration with Biogen for the treatment of neurological disorders; and collaboration and license agreement with GSK, AstraZeneca, Novartis, and Roche, as well as with Metagenomi. The company was incorporated in 1989 and is headquartered in Carlsbad, California.

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Income Statement (Annual)
Metric 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Revenue
Reconciled Cost Of Revenue $15,909,000 $11,215,000 $9,133,000 $14,116,000
Cost Of Revenue $15,909,000 $11,215,000 $9,133,000 $14,116,000
Total Revenue $943,711,000 $705,138,000 $787,647,000 $587,367,000
Operating Revenue $943,711,000 $705,138,000 $787,647,000 $587,367,000
Expenses
Interest Expense $84,282,000 $84,357,000 $81,457,000 $8,122,000
Total Expenses $1,325,428,000 $1,180,245,000 $1,141,377,000 $997,558,000
Other Income Expense $92,627,000 $105,464,000 $101,222,000 $160,328,000
Other Non Operating Income Expenses $-15,358,000 $1,331,000 $14,095,000 $-7,274,000
Net Non Operating Interest Income Expense $-90,582,000 $-90,457,000 $-81,457,000 $-8,122,000
Total Other Finance Cost $6,300,000 $6,100,000 $5,900,000 $5,300,000
Interest Expense Non Operating $84,282,000 $84,357,000 $81,457,000 $8,122,000
Operating Expense $1,309,519,000 $1,169,030,000 $1,132,244,000 $983,442,000
General And Administrative Expense $393,900,000 $267,500,000 $232,600,000 $150,300,000
Income & Earnings
Net Income From Continuing Operation Net Minority Interest $-381,387,000 $-453,897,000 $-366,286,000 $-269,722,000
Net Interest Income $-90,582,000 $-90,457,000 $-81,457,000 $-8,122,000
Normalized Income $-466,695,150 $-556,676,271 $-435,116,330 $-402,127,580
Net Income From Continuing And Discontinued Operation $-381,387,000 $-453,897,000 $-366,286,000 $-269,722,000
Total Operating Income As Reported $-381,684,000 $-475,081,000 $-353,730,000 $-410,191,000
Net Income Common Stockholders $-381,387,000 $-453,897,000 $-366,286,000 $-269,722,000
Net Income $-381,387,000 $-453,897,000 $-366,286,000 $-269,722,000
Net Income Including Noncontrolling Interests $-381,387,000 $-453,897,000 $-366,286,000 $-269,722,000
Net Income Continuous Operations $-381,387,000 $-453,897,000 $-366,286,000 $-269,722,000
Pretax Income $-379,601,000 $-460,068,000 $-333,965,000 $-257,985,000
Operating Income $-381,717,000 $-475,107,000 $-353,730,000 $-410,191,000
Gross Profit $927,802,000 $693,923,000 $778,514,000 $573,251,000
Special Income Charges - - - $0
Per Share
Diluted EPS $-2.38 $-3.04 $-2.56 $-1.90
Basic EPS $-2.38 $-3.04 $-2.56 $-1.90
Other
Tax Effect Of Unusual Items $22,676,850 $1,353,729 $18,296,670 $35,196,420
Tax Rate For Calcs $0 $0 $0 $0
Normalized EBITDA (Bullshit earnings) $-380,610,000 $-457,854,000 $-317,137,000 $-395,360,000
Total Unusual Items $107,985,000 $104,133,000 $87,127,000 $167,602,000
Total Unusual Items Excluding Goodwill $107,985,000 $104,133,000 $87,127,000 $167,602,000
Reconciled Depreciation $22,694,000 $21,990,000 $22,498,000 $22,105,000
EBITDA (Bullshit earnings) $-272,625,000 $-353,721,000 $-230,010,000 $-227,758,000
EBIT $-295,319,000 $-375,711,000 $-252,508,000 $-249,863,000
Diluted Average Shares $160,000,000 $150,000,000 $143,000,000 $142,000,000
Basic Average Shares $160,000,000 $150,000,000 $143,000,000 $142,000,000
Diluted NI Availto Com Stockholders $-381,387,000 $-453,897,000 $-366,286,000 $-269,722,000
Tax Provision $1,786,000 $-6,171,000 $32,321,000 $11,737,000
Gain On Sale Of Security $107,985,000 $104,133,000 $87,127,000 $167,602,000
Research And Development $915,619,000 $901,530,000 $899,625,000 $833,147,000
Selling General And Administration $393,900,000 $267,500,000 $232,619,000 $150,295,000
Other Gand A $352,000,000 $230,500,000 $205,100,000 $124,400,000
Salaries And Wages $41,900,000 $37,000,000 $27,500,000 $25,900,000
Minority Interests - - - $0
Restructuring And Mergern Acquisition - - - $0
Other Special Charges - - - -
Fetched: 2026-06-22
Balance Sheet (Annual)
Metric 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Assets
Net Tangible Assets $489,089,000 $588,351,000 $386,686,000 $572,887,000
Total Assets $3,523,836,000 $3,003,675,000 $2,990,072,000 $2,533,876,000
Total Non Current Assets $533,201,000 $383,385,000 $348,219,000 $331,182,000
Other Non Current Assets $171,604,000 $127,278,000 $105,280,000 $75,344,000
Current Assets $2,990,635,000 $2,620,290,000 $2,641,853,000 $2,202,694,000
Other Current Assets $237,092,000 $217,934,000 $205,433,000 $168,254,000
Inventory $10,048,000 $12,512,000 $7,441,000 $22,033,000
Receivables $66,059,000 $92,188,000 $97,778,000 $25,538,000
Other Receivables $66,059,000 $92,188,000 $97,778,000 $25,538,000
Cash Cash Equivalents And Short Term Investments $2,677,436,000 $2,297,656,000 $2,331,201,000 $1,986,869,000
Cash And Cash Equivalents $372,260,000 $242,077,000 $399,266,000 $276,472,000
Non Current Prepaid Assets - - - -
Goodwill And Other Intangible Assets - - - -
Other Intangible Assets - - - -
Debt
Net Debt $1,429,869,000 $1,012,687,000 $883,398,000 $913,782,000
Total Debt $2,064,512,000 $1,416,569,000 $1,453,539,000 $1,369,195,000
Long Term Debt And Capital Lease Obligation $1,609,826,000 $1,407,290,000 $1,400,376,000 $1,361,660,000
Long Term Debt $1,347,443,000 $1,245,485,000 $1,229,501,000 $1,182,719,000
Current Debt And Capital Lease Obligation $454,686,000 $9,279,000 $53,163,000 $7,535,000
Current Debt $454,686,000 $9,279,000 $53,163,000 $7,535,000
Other Current Borrowings $454,686,000 $9,279,000 $53,163,000 $7,535,000
Liabilities
Total Liabilities Net Minority Interest $3,034,747,000 $2,415,324,000 $2,603,386,000 $1,960,989,000
Total Non Current Liabilities Net Minority Interest $2,253,180,000 $2,106,006,000 $2,155,296,000 $1,649,428,000
Other Non Current Liabilities $551,353,000 $542,212,000 $513,736,000 -
Non Current Deferred Liabilities $92,001,000 $156,504,000 $241,184,000 $287,768,000
Current Liabilities $781,567,000 $309,318,000 $448,090,000 $311,561,000
Current Deferred Liabilities $73,761,000 $78,989,000 $151,128,000 $90,577,000
Payables And Accrued Expenses $136,884,000 $151,436,000 $176,072,000 $164,271,000
Payables $30,795,000 $42,998,000 $28,178,000 $24,170,000
Total Tax Payable $2,713,000 $34,000 $2,151,000 $6,249,000
Income Tax Payable $2,713,000 $34,000 $2,151,000 $6,249,000
Accounts Payable $28,082,000 $42,964,000 $26,027,000 $17,921,000
Other Current Liabilities - - - -
Equity
Common Stock Equity $489,089,000 $588,351,000 $386,686,000 $572,887,000
Total Equity Gross Minority Interest $489,089,000 $588,351,000 $386,686,000 $572,887,000
Stockholders Equity $489,089,000 $588,351,000 $386,686,000 $572,887,000
Gains Losses Not Affecting Retained Earnings $-25,281,000 $-30,811,000 $-32,645,000 $-57,480,000
Other Equity Adjustments $-25,281,000 $-30,811,000 $-32,645,000 $-57,480,000
Retained Earnings $-2,631,195,000 $-2,249,808,000 $-1,795,911,000 $-1,429,625,000
Other
Ordinary Shares Number $163,304,875 $157,908,815 $144,340,526 $142,057,736
Share Issued $163,304,875 $157,908,815 $144,340,526 $142,057,736
Tangible Book Value $489,089,000 $588,351,000 $386,686,000 $572,887,000
Invested Capital $2,291,218,000 $1,843,115,000 $1,669,350,000 $1,763,141,000
Working Capital $2,209,068,000 $2,310,972,000 $2,193,763,000 $1,891,133,000
Capital Lease Obligations $262,383,000 $161,805,000 $170,875,000 $178,941,000
Total Capitalization $1,836,532,000 $1,833,836,000 $1,616,187,000 $1,755,606,000
Additional Paid In Capital $3,145,402,000 $2,868,812,000 $2,215,098,000 $2,059,850,000
Capital Stock $163,000 $158,000 $144,000 $142,000
Common Stock $163,000 $158,000 $144,000 $142,000
Non Current Deferred Revenue $92,001,000 $156,504,000 $241,184,000 $287,768,000
Long Term Capital Lease Obligation $262,383,000 $161,805,000 $170,875,000 $178,941,000
Current Deferred Revenue $73,761,000 $78,989,000 $151,128,000 $90,577,000
Pensionand Other Post Retirement Benefit Plans Current $116,236,000 $69,614,000 $67,727,000 $49,178,000
Current Accrued Expenses $106,089,000 $108,438,000 $147,894,000 $140,101,000
Net PPE $361,597,000 $256,107,000 $242,939,000 $255,838,000
Accumulated Depreciation $-109,080,000 $-106,316,000 $-96,759,000 $-87,716,000
Gross PPE $470,677,000 $362,423,000 $339,698,000 $343,554,000
Leases $89,153,000 $54,375,000 $28,276,000 $28,357,000
Other Properties $238,549,000 $161,856,000 $171,896,000 $181,544,000
Machinery Furniture Equipment $101,174,000 $96,395,000 $89,729,000 $83,926,000
Buildings And Improvements $41,801,000 $41,228,000 $41,228,000 $41,158,000
Land And Improvements $0 $8,569,000 $8,569,000 $8,569,000
Properties $0 $0 $0 $0
Finished Goods $1,096,000 $276,000 $154,000 $164,000
Work In Process $7,913,000 $6,679,000 $5,477,000 $2,109,000
Raw Materials $1,039,000 $5,557,000 $1,810,000 $19,760,000
Other Short Term Investments $2,305,176,000 $2,055,579,000 $1,931,935,000 $1,710,397,000
Fetched: 2026-06-22
Cash Flow Statement (Annual)
Metric 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Free Cash Flow
Free Cash Flow $-325,667,000 $-551,288,000 $-335,502,000 $-294,469,000
Operating Activities
Operating Cash Flow $-268,583,000 $-500,947,000 $-307,513,000 $-274,370,000
Cash Flow From Continuing Operating Activities $-268,583,000 $-500,947,000 $-307,513,000 $-274,370,000
Operating Gains Losses $4,059,000 $13,328,000 $6,671,000 $-147,350,000
Investing Activities
Capital Expenditure $-57,084,000 $-50,341,000 $-27,989,000 $-20,099,000
Investing Cash Flow $-277,776,000 $-134,027,000 $-214,127,000 $-262,636,000
Cash Flow From Continuing Investing Activities $-277,776,000 $-134,027,000 $-214,127,000 $-262,636,000
Net Other Investing Changes - - $22,000 $254,083,000
Financing Activities
Issuance Of Capital Stock $192,604,000 $522,729,000 $49,442,000 $6,373,000
Financing Cash Flow $675,840,000 $478,058,000 $644,082,000 $-55,295,000
Cash Flow From Continuing Financing Activities $675,840,000 $478,058,000 $644,082,000 $-55,295,000
Net Other Financing Charges $-18,949,000 - $507,743,000 $-10,982,000
Net Common Stock Issuance $192,604,000 $522,729,000 $49,442,000 $6,373,000
Common Stock Issuance $192,604,000 $522,729,000 $49,442,000 $6,373,000
Repurchase Of Capital Stock - - - $0
Other
Repayment Of Debt $-267,815,000 $-44,671,000 $-488,103,000 $-50,686,000
Issuance Of Debt $770,000,000 $0 $575,000,000 $0
Interest Paid Supplemental Data $10,782,000 $10,869,000 $6,512,000 $2,898,000
End Cash Position $372,260,000 $242,077,000 $399,266,000 $276,472,000
Beginning Cash Position $242,077,000 $399,266,000 $276,472,000 $869,191,000
Effect Of Exchange Rate Changes $702,000 $-273,000 $352,000 $-418,000
Changes In Cash $129,481,000 $-156,916,000 $122,442,000 $-592,301,000
Net Issuance Payments Of Debt $502,185,000 $-44,671,000 $86,897,000 $-50,686,000
Net Short Term Debt Issuance $0 $-44,504,000 $-487,943,000 $0
Short Term Debt Payments $0 $-44,504,000 $-487,943,000 $0
Net Long Term Debt Issuance $502,185,000 $-167,000 $574,840,000 $-50,686,000
Long Term Debt Payments $-267,815,000 $-167,000 $-160,000 $-50,686,000
Long Term Debt Issuance $770,000,000 $0 $575,000,000 $0
Net Investment Purchase And Sale $-220,692,000 $-83,686,000 $-186,138,000 $-496,620,000
Sale Of Investment $1,697,870,000 $1,769,172,000 $1,584,676,000 $989,152,000
Purchase Of Investment $-1,918,562,000 $-1,852,858,000 $-1,770,814,000 $-1,485,772,000
Net Intangibles Purchase And Sale $-5,640,000 $-5,061,000 $-4,184,000 $-4,378,000
Purchase Of Intangibles $-5,640,000 $-5,061,000 $-4,184,000 $-4,378,000
Net PPE Purchase And Sale $-51,444,000 $-45,280,000 $-23,805,000 $-15,721,000
Purchase Of PPE $-51,444,000 $-45,280,000 $-23,805,000 $-15,721,000
Change In Working Capital $-51,215,000 $-209,390,000 $-77,260,000 $7,571,000
Change In Other Working Capital $-67,052,000 $-158,936,000 $9,869,000 $-65,035,000
Change In Other Current Assets $-33,212,000 $-25,857,000 $-33,763,000 $-27,235,000
Change In Payables And Accrued Expense $36,594,000 $-25,116,000 $21,162,000 $58,157,000
Change In Accrued Expense $51,954,000 $-41,106,000 $13,043,000 $57,063,000
Change In Payable $-15,360,000 $15,990,000 $8,119,000 $1,094,000
Change In Account Payable $-15,360,000 $15,990,000 $8,119,000 $1,094,000
Change In Inventory $-13,674,000 $-5,071,000 $-2,469,000 $5,326,000
Change In Receivables $26,129,000 $5,590,000 $-72,059,000 $36,358,000
Other Non Cash Items $27,127,000 $34,555,000 $29,940,000 $5,373,000
Stock Based Compensation $133,874,000 $130,200,000 $105,809,000 $100,264,000
Amortization Of Securities $-23,735,000 $-37,733,000 $-28,885,000 $7,389,000
Depreciation Amortization Depletion $22,694,000 $21,990,000 $22,498,000 $22,105,000
Depreciation And Amortization $22,694,000 $21,990,000 $22,498,000 $22,105,000
Amortization Cash Flow $2,439,000 $2,336,000 $2,559,000 $2,415,000
Amortization Of Intangibles $2,439,000 $2,336,000 $2,559,000 $2,415,000
Depreciation $20,255,000 $19,654,000 $19,939,000 $19,690,000
Gain Loss On Investment Securities $-9,280,000 $2,892,000 $1,589,000 $-149,911,000
Gain Loss On Sale Of PPE $-3,991,000 $7,404,000 $16,649,000 $531,000
Net Income From Continuing Operations $-381,387,000 $-453,897,000 $-366,286,000 $-269,722,000
Income Tax Paid Supplemental Data - - $48,334,000 $5,010,000
Proceeds From Stock Option Exercised - - $0 $0
Common Stock Payments - - - $0
Deferred Tax - - - $0
Deferred Income Tax - - - $0
Fetched: 2026-06-22