SEPN
Septerna, Inc.
Price Chart
Latest Quote
$36.17
+0.37 (+1.03%)
Current Price
| Previous Close | $35.80 |
| Open | $36.24 |
| Day High | $37.32 |
| Day Low | $34.51 |
| Volume | 269,111 |
Stock Information
| Shares Outstanding | 45.08M |
| Total Debt | $23.09M |
| Cash Equivalents | $347.40M |
| Revenue | $72.25M |
| Net Income | $-36.04M |
| Sector | Healthcare |
| Industry | Biotechnology |
| Market Cap | $1.63B |
| EPS (TTM) | $-0.80 |
| Exchange | NGM |
đ Comprehensive Analysis
Company Data
| Enterprise Value | $1.31B |
| Sales | $72.25M |
| Income | $-36.04M |
| Book/sh | $8.52 |
| Cash/sh | $7.71 |
| Employees | 130 |
Financial Ratios
| Quick Ratio | 4.63 |
| Current Ratio | 4.71 |
| Debt/Eq | 6.10 |
Returns & Margins
| ROA | -8.49% |
| ROE | -9.26% |
| Gross Margin | 100.00% |
| Operating Margin | -50.14% |
| Profit Margin | -49.88% |
Ownership
| Insider Ownership | 3.17% |
| Institutional Ownership | 102.65% |
| Insider & Institutional transactions data not available | |
Valuation Ratios
| Forward P/E | -13.60 |
| P/S | 22.56 |
| P/B | 4.24 |
Analyst Data
| Recommendation | strong_buy |
| Target Price | $45.78 |
Technical Indicators
| SMA20 | $31.80 |
| SMA50 | $27.75 |
| SMA200 | $24.77 |
| RSI | 76.63 |
| ATR | 1.9885 |
| Shares Float | 23.12M |
| Short Float | 11.47% |
| Short Ratio | 8.59 |
| Rel Volume | 0.90 |
Performance History
| Week | +6.29% |
| Month | +36.44% |
| Quarter | +48.97% |
| 6 Months | +37.90% |
| YTD | +29.27% |
| Year | +253.22% |
| 10 Years | +69.02% |
Stock Score:
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Recent Price History
| Date | Close | Volume |
|---|---|---|
| 2026-06-18 | $36.17 | 283,300 |
| 2026-06-17 | $35.80 | 325,100 |
| 2026-06-16 | $35.17 | 284,000 |
| 2026-06-15 | $36.03 | 287,800 |
| 2026-06-12 | $35.95 | 475,900 |
| 2026-06-11 | $34.03 | 513,300 |
| 2026-06-10 | $30.47 | 171,900 |
| 2026-06-09 | $31.01 | 277,800 |
| 2026-06-08 | $30.41 | 327,300 |
| 2026-06-05 | $31.15 | 211,700 |
| 2026-06-04 | $31.37 | 290,700 |
| 2026-06-03 | $30.55 | 286,600 |
| 2026-06-02 | $29.94 | 603,600 |
| 2026-06-01 | $29.98 | 359,300 |
| 2026-05-29 | $30.20 | 270,500 |
| 2026-05-28 | $31.05 | 219,100 |
| 2026-05-27 | $29.79 | 178,700 |
| 2026-05-26 | $30.65 | 347,400 |
| 2026-05-22 | $28.36 | 347,200 |
| 2026-05-21 | $27.92 | 232,400 |
| 2026-05-20 | $28.01 | 226,700 |
| 2026-05-19 | $26.51 | 366,800 |
About Septerna, Inc.
Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves' disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women's health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.
đ° Latest News
Party Time: Brokers Just Made Major Increases To Their Septerna, Inc. (NASDAQ:SEPN) Earnings Forecasts
Simply Wall St. âĸ 2026-05-17T14:47:53Z
Earnings Update: Septerna, Inc. (NASDAQ:SEPN) Just Reported And Analysts Are Boosting Their Estimates
Simply Wall St. âĸ 2026-05-15T14:08:48Z
Septerna, Inc. (SEPN) Reports Q1 Loss, Tops Revenue Estimates
Zacks âĸ 2026-05-11T21:25:03Z
Liquidia Corporation (LQDA) Surpasses Q1 Earnings and Revenue Estimates
Zacks âĸ 2026-05-11T11:45:03Z
How Analyst Upgrade and Conference Spotlight Will Impact Septerna (SEPN) Investors
Simply Wall St. âĸ 2026-05-08T13:19:24Z
Zymeworks Inc. (ZYME) Reports Q1 Loss, Misses Revenue Estimates
Zacks âĸ 2026-05-07T23:05:24Z
Axsome Therapeutics (AXSM) Reports Q1 Loss, Beats Revenue Estimates
Zacks âĸ 2026-05-04T12:15:03Z
Septerna, Inc. (SEPN) Reports Q4 Loss, Tops Revenue Estimates
Zacks âĸ 2026-03-09T21:20:04Z
Does SEP-631âs Phase 1 Proof-of-Mechanism and 2026 Trial Plan Reshape Septernaâs Mast Cell Strategy (SEPN)?
Simply Wall St. âĸ 2026-03-03T14:09:02Z
Assessing Septerna (SEPN) Valuation After Recent Share Price Pullback And One Year 40.63% Return
Simply Wall St. âĸ 2026-01-10T21:08:05Z
Period:
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Income Statement (Annual)
| Metric | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 |
|---|---|---|---|---|
| Revenue | ||||
| Total Revenue | $45,951,000 | $1,075,000 | $151,000 | $0 |
| Operating Revenue | $45,951,000 | $1,075,000 | $151,000 | $0 |
| Expenses | ||||
| Total Expenses | $126,748,000 | $81,898,000 | $45,701,000 | $27,967,000 |
| Other Income Expense | $12,400,000 | $-90,000 | $47,635,000 | - |
| Other Non Operating Income Expenses | $-100,000 | $-90,000 | $10,000 | - |
| Net Non Operating Interest Income Expense | $19,530,000 | $8,617,000 | $2,786,000 | $291,000 |
| Operating Expense | $126,748,000 | $81,898,000 | $45,701,000 | $27,967,000 |
| General And Administrative Expense | $29,164,000 | $16,561,000 | $9,722,000 | $5,923,000 |
| Income & Earnings | ||||
| Net Income From Continuing Operation Net Minority Interest | $-48,879,000 | $-71,798,000 | $4,180,000 | $-27,676,000 |
| Net Interest Income | $19,530,000 | $8,617,000 | $2,786,000 | $291,000 |
| Interest Income | $19,530,000 | $8,617,000 | $2,786,000 | $291,000 |
| Normalized Income | $-61,379,000 | $-71,798,000 | $-36,682,250 | $-27,676,000 |
| Net Income From Continuing And Discontinued Operation | $-48,879,000 | $-71,798,000 | $4,180,000 | $-27,676,000 |
| Total Operating Income As Reported | $-68,297,000 | $-80,823,000 | $2,075,000 | $-27,967,000 |
| Net Income Common Stockholders | $-48,879,000 | $-71,798,000 | $567,000 | $-27,676,000 |
| Net Income | $-48,879,000 | $-71,798,000 | $4,180,000 | $-27,676,000 |
| Net Income Including Noncontrolling Interests | $-48,879,000 | $-71,798,000 | $4,180,000 | $-27,676,000 |
| Net Income Continuous Operations | $-48,879,000 | $-71,798,000 | $4,180,000 | $-27,676,000 |
| Pretax Income | $-48,867,000 | $-72,296,000 | $4,871,000 | $-27,676,000 |
| Special Income Charges | $12,500,000 | $0 | $47,625,000 | $0 |
| Interest Income Non Operating | $19,530,000 | $8,617,000 | $2,786,000 | $291,000 |
| Operating Income | $-80,797,000 | $-80,823,000 | $-45,550,000 | $-27,967,000 |
| Average Dilution Earnings | - | - | $62,000 | - |
| Per Share | ||||
| Diluted EPS | $-1.10 | $-7.26 | $0.03 | $-1.42 |
| Basic EPS | $-1.10 | $-7.26 | $0.03 | $-1.42 |
| Other | ||||
| Tax Effect Of Unusual Items | $0 | $0 | $6,762,750 | $0 |
| Tax Rate For Calcs | $0 | $0 | $0 | $0 |
| Normalized EBITDA (Bullshit earnings) | $-91,693,000 | $-79,422,000 | $-92,327,000 | $-27,390,000 |
| Total Unusual Items | $12,500,000 | $0 | $47,625,000 | $0 |
| Total Unusual Items Excluding Goodwill | $12,500,000 | $0 | $47,625,000 | $0 |
| Reconciled Depreciation | $1,604,000 | $1,401,000 | $848,000 | $577,000 |
| EBITDA (Bullshit earnings) | $-79,193,000 | $-79,422,000 | $-44,702,000 | $-27,390,000 |
| EBIT | $-80,797,000 | $-80,823,000 | $-45,550,000 | $-27,967,000 |
| Diluted Average Shares | $44,258,338 | $9,891,126 | $19,495,760 | $19,495,760 |
| Basic Average Shares | $44,258,338 | $9,891,126 | $19,495,760 | $19,495,760 |
| Diluted NI Availto Com Stockholders | $-48,879,000 | $-71,798,000 | $629,000 | $-27,676,000 |
| Tax Provision | $12,000 | $-498,000 | $691,000 | $0 |
| Gain On Sale Of Ppe | $12,500,000 | $0 | $47,625,000 | $0 |
| Research And Development | $97,584,000 | $65,337,000 | $35,979,000 | $22,044,000 |
| Selling General And Administration | $29,164,000 | $16,561,000 | $9,722,000 | $5,923,000 |
| Other Gand A | $29,164,000 | $16,561,000 | $9,722,000 | $5,923,000 |
| Otherunder Preferred Stock Dividend | - | $0 | $3,613,000 | $0 |
Fetched: 2026-06-19
Balance Sheet (Annual)
| Metric | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 |
|---|---|---|---|---|
| Assets | ||||
| Net Tangible Assets | $381,926,000 | $420,047,000 | $-38,374,000 | $-44,201,000 |
| Total Assets | $596,187,000 | $456,554,000 | $130,867,000 | $36,119,000 |
| Total Non Current Assets | $185,223,000 | $99,730,000 | $18,189,000 | $4,229,000 |
| Other Non Current Assets | $1,721,000 | $1,172,000 | $1,002,000 | $1,124,000 |
| Investmentin Financial Assets | $157,569,000 | $69,866,000 | $0 | - |
| Current Assets | $410,964,000 | $356,824,000 | $112,678,000 | $31,890,000 |
| Other Current Assets | $1,152,000 | $239,000 | $92,000 | $204,000 |
| Prepaid Assets | $4,983,000 | $4,538,000 | $1,327,000 | $1,079,000 |
| Receivables | $13,740,000 | $1,124,000 | $22,776,000 | $0 |
| Accrued Interest Receivable | $3,384,000 | $953,000 | - | - |
| Accounts Receivable | $10,356,000 | $171,000 | $151,000 | $0 |
| Cash Cash Equivalents And Short Term Investments | $391,089,000 | $350,923,000 | $88,483,000 | $30,607,000 |
| Cash And Cash Equivalents | $120,722,000 | $238,196,000 | $88,483,000 | $30,607,000 |
| Other Receivables | - | - | $22,625,000 | - |
| Cash Equivalents | - | - | $86,574,000 | $29,607,000 |
| Cash Financial | - | - | $1,909,000 | $1,000,000 |
| Debt | ||||
| Total Debt | $23,625,000 | $25,476,000 | $12,566,000 | $710,000 |
| Long Term Debt And Capital Lease Obligation | $21,413,000 | $23,625,000 | $12,566,000 | $0 |
| Current Debt And Capital Lease Obligation | $2,212,000 | $1,851,000 | - | $710,000 |
| Liabilities | ||||
| Total Liabilities Net Minority Interest | $214,261,000 | $36,507,000 | $169,241,000 | $80,320,000 |
| Total Non Current Liabilities Net Minority Interest | $127,330,000 | $23,658,000 | $162,327,000 | $74,777,000 |
| Non Current Deferred Liabilities | $105,917,000 | $0 | - | - |
| Current Liabilities | $86,931,000 | $12,849,000 | $6,914,000 | $5,543,000 |
| Other Current Liabilities | $148,000 | $78,000 | $85,000 | $50,000 |
| Current Deferred Liabilities | $62,269,000 | $0 | - | - |
| Payables And Accrued Expenses | $16,377,000 | $6,791,000 | $3,875,000 | $3,077,000 |
| Payables | $10,283,000 | $3,200,000 | $2,837,000 | $3,071,000 |
| Accounts Payable | $10,283,000 | $3,200,000 | $2,637,000 | $3,071,000 |
| Other Non Current Liabilities | - | $33,000 | $546,000 | $83,000 |
| Total Tax Payable | - | $0 | $200,000 | $0 |
| Income Tax Payable | - | $0 | $200,000 | $0 |
| Equity | ||||
| Common Stock Equity | $381,926,000 | $420,047,000 | $-38,374,000 | $-44,201,000 |
| Total Equity Gross Minority Interest | $381,926,000 | $420,047,000 | $-38,374,000 | $-44,201,000 |
| Stockholders Equity | $381,926,000 | $420,047,000 | $-38,374,000 | $-44,201,000 |
| Gains Losses Not Affecting Retained Earnings | $617,000 | $56,000 | $0 | - |
| Other Equity Adjustments | $617,000 | $56,000 | - | - |
| Retained Earnings | $-167,253,000 | $-118,374,000 | $-46,576,000 | $-50,756,000 |
| Preferred Securities Outside Stock Equity | - | $0 | $149,215,000 | $74,694,000 |
| Other | ||||
| Ordinary Shares Number | $44,806,272 | $44,422,505 | $42,002,794 | $42,002,794 |
| Share Issued | $44,806,272 | $44,422,505 | $42,002,794 | $42,002,794 |
| Tangible Book Value | $381,926,000 | $420,047,000 | $-38,374,000 | $-44,201,000 |
| Invested Capital | $381,926,000 | $420,047,000 | $-38,374,000 | $-44,201,000 |
| Working Capital | $324,033,000 | $343,975,000 | $105,764,000 | $26,347,000 |
| Capital Lease Obligations | $23,625,000 | $25,476,000 | $12,566,000 | $710,000 |
| Total Capitalization | $381,926,000 | $420,047,000 | $-38,374,000 | $-44,201,000 |
| Additional Paid In Capital | $548,517,000 | $538,321,000 | $8,199,000 | $6,552,000 |
| Capital Stock | $45,000 | $44,000 | $3,000 | $3,000 |
| Common Stock | $45,000 | $44,000 | $3,000 | $3,000 |
| Preferred Stock | $0 | $0 | $0 | - |
| Non Current Deferred Revenue | $105,917,000 | $0 | - | - |
| Long Term Capital Lease Obligation | $21,413,000 | $23,625,000 | $12,566,000 | $0 |
| Current Deferred Revenue | $62,269,000 | $0 | - | - |
| Current Capital Lease Obligation | $2,212,000 | $1,851,000 | $0 | $710,000 |
| Pensionand Other Post Retirement Benefit Plans Current | $5,925,000 | $4,129,000 | $2,954,000 | $1,706,000 |
| Current Accrued Expenses | $6,094,000 | $3,591,000 | $1,038,000 | $6,000 |
| Investments And Advances | $157,569,000 | $69,866,000 | $0 | - |
| Available For Sale Securities | $157,569,000 | $69,866,000 | - | - |
| Net PPE | $25,933,000 | $28,692,000 | $17,187,000 | $3,105,000 |
| Accumulated Depreciation | $-4,352,000 | $-2,929,000 | $-1,622,000 | $-798,000 |
| Gross PPE | $30,285,000 | $31,621,000 | $18,809,000 | $3,903,000 |
| Leases | $717,000 | $717,000 | $389,000 | $0 |
| Construction In Progress | $107,000 | $0 | - | - |
| Other Properties | $27,838,000 | $29,281,000 | $17,489,000 | $3,672,000 |
| Machinery Furniture Equipment | $1,623,000 | $1,623,000 | $931,000 | $231,000 |
| Properties | $0 | $0 | $0 | $0 |
| Other Short Term Investments | $270,367,000 | $112,727,000 | $0 | - |
Fetched: 2026-06-19
Cash Flow Statement (Annual)
| Metric | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 |
|---|---|---|---|---|
| Free Cash Flow | ||||
| Free Cash Flow | $109,671,000 | $-69,573,000 | $-41,601,000 | $-24,592,000 |
| Operating Activities | ||||
| Operating Cash Flow | $110,189,000 | $-67,470,000 | $-38,723,000 | $-23,303,000 |
| Cash Flow From Continuing Operating Activities | $110,189,000 | $-67,470,000 | $-38,723,000 | $-23,303,000 |
| Operating Gains Losses | $-12,500,000 | - | $-47,625,000 | - |
| Investing Activities | ||||
| Capital Expenditure | $-518,000 | $-2,103,000 | $-2,878,000 | $-1,289,000 |
| Investing Cash Flow | $-229,352,000 | $-160,598,000 | $22,122,000 | $-1,289,000 |
| Cash Flow From Continuing Investing Activities | $-229,352,000 | $-160,598,000 | $22,122,000 | $-1,289,000 |
| Net Other Investing Changes | $12,500,000 | $22,625,000 | $25,000,000 | - |
| Financing Activities | ||||
| Repurchase Of Capital Stock | $-1,000 | $-1,000 | $-1,000 | - |
| Issuance Of Capital Stock | $0 | $377,730,000 | $74,521,000 | $29,969,000 |
| Financing Cash Flow | $1,689,000 | $377,781,000 | $74,520,000 | $30,051,000 |
| Cash Flow From Continuing Financing Activities | $1,689,000 | $377,781,000 | $74,520,000 | $30,051,000 |
| Net Preferred Stock Issuance | $0 | $74,942,000 | $74,521,000 | $29,969,000 |
| Preferred Stock Issuance | $0 | $74,942,000 | $74,521,000 | $29,969,000 |
| Net Common Stock Issuance | $-1,000 | $302,787,000 | $-1,000 | - |
| Common Stock Issuance | $0 | $302,788,000 | $0 | - |
| Other | ||||
| Income Tax Paid Supplemental Data | $0 | $232,000 | $75,000 | $0 |
| End Cash Position | $121,627,000 | $239,101,000 | $89,388,000 | $31,469,000 |
| Beginning Cash Position | $239,101,000 | $89,388,000 | $31,469,000 | $26,010,000 |
| Changes In Cash | $-117,474,000 | $149,713,000 | $57,919,000 | $5,459,000 |
| Proceeds From Stock Option Exercised | $1,690,000 | $52,000 | $0 | $82,000 |
| Common Stock Payments | $-1,000 | $-1,000 | $-1,000 | - |
| Net Investment Purchase And Sale | $-241,334,000 | $-181,120,000 | $0 | - |
| Sale Of Investment | $209,616,000 | $32,270,000 | $0 | - |
| Purchase Of Investment | $-450,950,000 | $-213,390,000 | $0 | - |
| Net PPE Purchase And Sale | $-518,000 | $-2,103,000 | $-2,878,000 | $-1,289,000 |
| Purchase Of PPE | $-518,000 | $-2,103,000 | $-2,878,000 | $-1,289,000 |
| Change In Working Capital | $162,777,000 | $248,000 | $926,000 | $1,746,000 |
| Change In Other Working Capital | $166,335,000 | $448,000 | $-770,000 | $-573,000 |
| Change In Other Current Assets | $-554,000 | $-170,000 | $165,000 | $244,000 |
| Change In Payables And Accrued Expense | $10,962,000 | $4,287,000 | $1,818,000 | $3,100,000 |
| Change In Accrued Expense | $4,359,000 | $3,564,000 | $2,471,000 | $1,374,000 |
| Change In Payable | $6,603,000 | $723,000 | $-653,000 | $1,726,000 |
| Change In Account Payable | $6,603,000 | $723,000 | $-653,000 | $1,726,000 |
| Change In Prepaid Assets | $-3,781,000 | $-4,297,000 | $-136,000 | $-1,025,000 |
| Change In Receivables | $-10,185,000 | $-20,000 | $-151,000 | $0 |
| Changes In Account Receivables | $-10,185,000 | $-20,000 | $-151,000 | $0 |
| Other Non Cash Items | $2,159,000 | $1,428,000 | $837,000 | $530,000 |
| Stock Based Compensation | $8,476,000 | $3,152,000 | $1,620,000 | $1,520,000 |
| Amortization Of Securities | $-3,448,000 | $-1,410,000 | $0 | - |
| Deferred Tax | $0 | $-491,000 | $491,000 | $0 |
| Deferred Income Tax | $0 | $-491,000 | $491,000 | $0 |
| Depreciation Amortization Depletion | $1,604,000 | $1,401,000 | $848,000 | $577,000 |
| Depreciation And Amortization | $1,604,000 | $1,401,000 | $848,000 | $577,000 |
| Net Income From Continuing Operations | $-48,879,000 | $-71,798,000 | $4,180,000 | $-27,676,000 |
| Gain Loss On Sale Of PPE | - | - | $30,000 | $0 |
Fetched: 2026-06-19